![]() ![]() 2005 Li and Saunders 2005 McConkey and Varki 2005). These are fascinating questions, and a major challenge is to explain how genomic differences contributed to this process ( Goodman 1999 Gagneux and Varki 2001 Klein and Takahata 2002 Carroll 2003 Olson and Varki 2003 Enard and Pääbo 2004 Gagneux 2004 Ruvolo 2004 Goodman et al. What makes humans different from their closest evolutionary relatives, and how, why, and when did these changes occur? Humans ( Homo sapiens) and chimpanzees ( Pan troglodytes) last shared a common ancestor ∼5-7 million years ago (Mya) ( Chen and Li 2001 Brunet et al. That these likely represent only the tip of the iceberg. We also cite some known genetic differences between humans and great apes, realizing These two approaches will intersect at many levelsĪnd should be considered complementary. In the human population that impact unique aspects of the human condition. Genomic surveys, on genes that may contribute to known differences in phenotypes or disease incidence/severity, or on mutations Meanwhile, candidate gene approaches can be based on such While simultaneously identifying potential targets of opportunity. ![]() Genome-wide surveys could eliminate the majority of genomic sequence differences from consideration, It is logical to tackle the genetic aspects via both genome-wide analysesĪnd candidate gene studies. “phenomes” and the relevant environmental influences. Important differences scattered throughout these genomes while integrating these data with emerging knowledge about the corresponding The challenge is to identify the many evolutionarily, physiologically, and biomedically The difference between the two genomes is actually not ∼1%, but ∼4%-comprising ∼35 million single nucleotide differences and Humans and chimpanzees shared a common ancestor ∼5-7 million years ago (Mya). The chimpanzee genome sequence is a long-awaited milestone, providing opportunities to explore primate evolution and geneticĬontributions to human physiology and disease. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |